Gardner Lab

Publications

Preprints:

  1. A mitochondrial electron transport chain with atypical subunit composition confers oxygen sensitivity to a mammalian chemoreceptor. bioRxiv 2021 Oct 4. Alba Timón-Gómez*, Alexandra L. Scharr*, Nicholas Y. Wong, Erwin Ni, Arijit Roy, Min Liu, Julisia Chau, Jack L. Lampert, Homza Hireed, Noah S. Kim, Masood Jan, Alexander R. Gupta, Ryan W. Day, James M. Gardner, Richard J. A. Wilson, Antoni Barrientos✝, Andy J. Chang✝ ;*Co-first authors; ✝Co-corresponding authors.
  2. Antigen presentation by type 3 innate lymphoid cells instructs the differentiation of gut microbiota-specific regulatory T cells. bioRxiv 2021 Nov 19. Ranit Kedmi, Tariq Najar, Kailin R. Mesa, Allyssa Grayson, Lina Kroehling, Yuhan Hao, Stephanie Hao, Maria Pokrovskii, Mo Xu, Jhimmy Talbot, Jiaxi Wang, Mark S. Anderson, James M. Gardner, Terri M. Laufer, Iannis Aifantis, Juliet M. Bartleson, Paul M. Allen, Marlon Stoeckius, Dan R. Littman

Peer-reviewed:

  1. RORγt-lineage APCs: The Aire apparent. Science Immunol. 2022 Dec 23. Gardner JM, Liston A. 7(78):eade9240. doi: 10.1126/sciimmunol.ade9240. PMID: 36525506.

  2. A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation. Nature. 2022 Sep 07. Kedmi R, Najar TA, Mesa KR, Grayson A, Kroehling L, Hao Y, Hao S, Pokrovskii M, Xu M, Talbot J, Wang J, Germino J, Lareau CA, Satpathy AT, Anderson MS, Laufer TM, Aifantis I, Bartleson JM, Allen PM, Paidassi H, Gardner JM, Stoeckius M, Littman DR. PMID: 36071167.

  3. A novel microsurgical reconstruction technique in a living-related liver donor hepatic artery dissection using the native hepatic artery. Am J Transplant. 2022 May 25. Sitta R, Roberts J, Gardner J, Ascher N, Piper M. PMID: 35612995.

  4. Nodular Regenerative Hyperplasia After Liver Transplant; It's All in the Presentation. Front Surg. 2022; 9:876818. Chen AK, Lunow-Luke T, Yamaguchi S, Praglin C, Agudelo E, Mehta N, Dirks R, Braun HJ, Gardner JM, Roberts JP, Syed SM, Roll GR. PMID: 35656084; PMCID: PMC9152168.

  5. The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. Science. 2022 05 13; 376(6594):eabl4896. Tabula Sapiens Consortium*, Jones RC, Karkanias J, Krasnow MA, Pisco AO, Quake SR, Salzman J, Yosef N, Bulthaup B, Brown P, Harper W, Hemenez M, Ponnusamy R, Salehi A, Sanagavarapu BA, Spallino E, Aaron KA, Concepcion W, Gardner JM, Kelly B, Neidlinger N, Wang Z, Crasta S, Kolluru S, Morri M, Pisco AO, Tan SY, Travaglini KJ, Xu C, Alcántara-Hernández M, Almanzar N, Antony J, Beyersdorf B, Burhan D, Calcuttawala K, Carter MM, Chan CKF, Chang CA, Chang S, Colville A, Crasta S, Culver RN, Cvijovic I, D'Amato G, Ezran C, Galdos FX, Gillich A, Goodyer WR, Hang Y, Hayashi A, Houshdaran S, Huang X, Irwin JC, Jang S, Juanico JV, Kershner AM, Kim S, Kiss B, Kolluru S, Kong W, Kumar ME, Kuo AH, Leylek R, Li B, Loeb GB, Lu WJ, Mantri S, Markovic M, McAlpine PL, de Morree A, Morri M, Mrouj K, Mukherjee S, Muser T, Neuhöfer P, Nguyen TD, Perez K, Phansalkar R, Pisco AO, Puluca N, Qi Z, Rao P, Raquer-McKay H, Schaum N, Scott B, Seddighzadeh B, Segal J, Sen S, Sikandar S, Spencer SP, Steffes LC, Subramaniam VR, Swarup A, Swift M, Travaglini KJ, Van Treuren W, Trimm E, Veizades S, Vijayakumar S, Vo KC, Vorperian SK, Wang W, Weinstein HNW, Winkler J, Wu TTH, Xie J, Yung AR, Zhang Y, Detweiler AM, Mekonen H, Neff NF, Sit RV, Tan M, Yan J, Bean GR, Charu V, Forgó E, Martin BA, Ozawa MG, Silva O, Tan SY, Toland A, Vemuri VNP, Afik S, Awayan K, Botvinnik OB, Byrne A, Chen M, Dehghannasiri R, Detweiler AM, Gayoso A, Granados AA, Li Q, Mahmoudabadi G, McGeever A, de Morree A, Olivieri JE, Park M, Pisco AO, Ravikumar N, Salzman J, Stanley G, Swift M, Tan M, Tan W, Tarashansky AJ, Vanheusden R, Vorperian SK, Wang P, Wang S, Xing G, Xu C, Yosef N, Alcántara-Hernández M, Antony J, Chan CKF, Chang CA, Colville A, Crasta S, Culver R, Dethlefsen L, Ezran C, Gillich A, Hang Y, Ho PY, Irwin JC, Jang S, Kershner AM, Kong W, Kumar ME, Kuo AH, Leylek R, Liu S, Loeb GB, Lu WJ, Maltzman JS, Metzger RJ, de Morree A, Neuhöfer P, Perez K, Phansalkar R, Qi Z, Rao P, Raquer-McKay H, Sasagawa K, Scott B, Sinha R, Song H, Spencer SP, Swarup A, Swift M, Travaglini KJ, Trimm E, Veizades S, Vijayakumar S, Wang B, Wang W, Winkler J, Xie J, Yung AR, Artandi SE, Beachy PA, Clarke MF, Giudice LC, Huang FW, Huang KC, Idoyaga J, Kim SK, Krasnow M, Kuo CS, Nguyen P, Quake SR, Rando TA, Red-Horse K, Reiter J, Relman DA, Sonnenburg JL, Wang B, Wu A, Wu SM, Wyss-Coray T. PMID: 35549404.

  6. Thymic and extrathymic Aire-expressing cells in maternal-fetal tolerance. Immunol Rev. 2022 07; 308(1):93-104. Sun IH, Gillis-Buck E, Mackenzie TC, Gardner JM. PMID: 35535447.

  7. Internal hernia involving the transplant ureter after simultaneous pancreas and kidney transplant - and the atypical management of a consequent transplant ureteral injury. Clin Transplant. 2022 Jul; 36(7):e14675. Gupta AR, Kelly YM, Syed SM, Gardner JM. PMID: 35430751.

  8. Procurement of Deceased Donor Parathyroid Glands With the Aid of Near-infrared Autofluorescence Imaging. Transplant Direct. 2022 Apr; 8(4):e1306. Ward CJ, Kelly YM, Syed SM, Meier RPH, Ando T, Wisel SA, Gardner JM, Stock PG, Duh QY. PMID: 35310601; PMCID: PMC8923582.

  9. Cell types of origin of the cell-free transcriptome. Nat Biotechnol. 2022 Jun; 40(6):855-861. Vorperian SK, Moufarrej MN, Tabula Sapiens Consortium, Quake SR. PMID: 35132263; PMCID: PMC9200634.

  10. Advantages and Limitations of Clinical Scores for Donation After Circulatory Death Liver Transplantation. Front Surg. 2021; 8:808733. Meier RPH, Kelly Y, Yamaguchi S, Braun HJ, Lunow-Luke T, Adelmann D, Niemann C, Maluf DG, Dietch ZC, Stock PG, Kang SM, Feng S, Posselt AM, Gardner JM, Syed SM, Hirose R, Freise CE, Ascher NL, Roberts JP, Roll GR. PMID: 35071316; PMCID: PMC8766343.

  11. Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium. Science Immunol. 2021 Nov 12; 6(65). Wang J*, Lareau CA*, Bautista JL, Gupta AR, Sandor K, Germino J, Yin Y, Arvedson MP, Reeder GC, Cramer NT, Xie F, Ntranos V, Satpathy AT, Anderson MS, & Gardner JM PMID: 34767455. *Co-first authors.

  12. RNA splicing programs define tissue compartments and cell types at single-cell resolution. Elife. 2021 09 13; 10. Olivieri JE, Dehghannasiri R, Wang PL, Jang S, de Morree A, Tan SY, Ming J, Ruohao Wu A, Tabula Sapiens Consortium, Quake SR, Krasnow MA, Salzman J. PMID: 34515025; PMCID: PMC8563012.

  13. Extrathymic Aire-expressing cells support maternal-fetal tolerance. Sci Immunol. 2021 Jul 16; 6(61).Gillis-Buck E, Miller H, Sirota M, Sanders SJ, Ntranos V, Anderson MS, Gardner JM✝, MacKenzie TC✝.  PMID: 34272228. ✝Co-corresponding authors.

  14. A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance. J Exp Med. 2021 Aug 02; 218(8).Warshauer JT, Belk JA, Chan AY, Wang J, Gupta AR, Shi Q, Skartsis N, Peng Y, Phipps JD, Acenas D, Smith JA, Tamaki SJ, Tang Q, Gardner JM, Satpathy AT, Anderson MS.  PMID: 34115115.

  15. Transplantation From Older Donors: Can Senolytics Turn Back the Clock? Transplantation. 2021 04 01; 105(4):681-682.Dixon W, Feng S, Gardner J.  PMID: 33760787.

  16. Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla. Nat Commun. 2021 02 17; 12(1):1096.Bautista JL, Cramer NT, Miller CN, Chavez J, Berrios DI, Byrnes LE, Germino J, Ntranos V, Sneddon JB, Burt TD, Gardner JM, Ye CJ, Anderson MS, Parent AV.  PMID: 33597545.

  17. Surgical, Interventional, and Medical Palliation of Portal Hypertension. Am Surg. 2020 Nov; 86(11):1467-1472.Lin JA, Gardner JM, Kolli KP, Cook AC.  PMID: 33153284.

  18. CON: Portal Vein Thrombosis Does Not Impact Liver Transplantation Outcomes. Clin Liver Dis (Hoboken). 2020 Oct; 16(4):132.Sherman C, Syed S, Gardner J, Yao FY.  PMID: 33163163.

  19. COVID-19 and Abdominal Transplant: A Stepwise Approach to Practice During Pandemic Conditions. Transplantation. 2020 11; 104(11):2215-2220.Syed SM, Gardner J, Roll G, Webber A, Mehta N, Shoji J, Adelmann D, Niemann C, Braun HJ, Mello A, Yao F, Posselt A, Kang SM, Hirose R, Roberts J, Feng S, Ascher N, Stock P, Freise C.  PMID: 32639408.

  20. Curr Hepatology Rep. Non-selective Beta-Blockers in Decompensated Cirrhosis. 2020.Huang, A.C., Gardner, J.M. & Hameed, B. View Publication.

  21. Ethical Issues in the COVID Era: Doing the Right Thing Depends on Location, Resources, and Disease Burden. Transplantation. 2020 07; 104(7):1316-1320.Stock PG, Wall A, Gardner J, Domínguez-Gil B, Chadban S, Muller E, Dittmer I, Tullius SG, TTS Ethics Committee .  PMID: 32569002.

  22. Pancreas-After-Islet Transplantation in Nonuremic Type 1 Diabetes: A Strategy for Restoring Durable Insulin Independence. Am J Transplant. 2017 Sep; 17(9):2444-2450.Wisel SA, Gardner JM, Roll GR, Harbell J, Freise CE, Feng S, Kang SM, Hirose R, Kaufman DB, Posselt AM, Stock PG.  PMID: 28489277.

  23. Effect of intratonsillar injection of steroids on the palatine tonsils of rabbits. Laryngoscope. 2014 Dec; 124(12):2811-7.Cho DY, Sinha SR, Gardner JM, Schaller MP, Pamnani RD, Felt SA, Barral JK, Messner AH.  PMID: 24114886.

  24. Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell population. Cell Rep. 2013 Oct 17; 5(1):166-79.Metzger TC, Khan IS, Gardner JM, Mouchess ML, Johannes KP, Krawisz AK, Skrzypczynska KM, Anderson MS.  PMID: 24095736.

  25. Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4? T cells. Immunity. 2013 Sep 19; 39(3):560-72. Gardner JM, Metzger TC, McMahon EJ, Au-Yeung BB, Krawisz AK, Lu W, Price JD, Johannes KP, Satpathy AT, Murphy KM, Tarbell KV, Weiss A, Anderson MS.  PMID: 23993652.

  26. Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo. J Exp Med. 2012 Sep 24; 209(10):1713-22, S1-19.Yadav M, Louvet C, Davini D, Gardner JM, Martinez-Llordella M, Bailey-Bucktrout S, Anthony BA, Sverdrup FM, Head R, Kuster DJ, Ruminski P, Weiss D, Von Schack D, Bluestone JA.  PMID: 22966003.

  27. Immunoendocrinology: Scientific and Clinical Aspects. Eisenbarth, GS (Ed.). The Mouse Model of Autoimmune Polyglandular Syndrome Type I. 2011; 1(1):95-113. Gardner JM, Anderson MA.

  28. AIRE in the thymus and beyond. Curr Opin Immunol. 2009 Dec; 21(6):582-9. Gardner JM, Fletcher AL, Anderson MS, Turley SJ.  PMID: 19833494.

  29. The sickness unto Deaf. Nat Immunol. 2009 Sep; 10(9):934-6. Gardner JM, Anderson MS.  PMID: 19692991.

  30. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science. 2008 Aug 08; 321(5890):843-7.Gardner JM, Devoss JJ, Friedman RS, Wong DJ, Tan YX, Zhou X, Johannes KP, Su MA, Chang HY, Krummel MF, Anderson MS.  PMID: 18687966.

  31. Mycobacterium tuberculosis-specific CD8+ T cells preferentially recognize heavily infected cells. Am J Respir Crit Care Med. 2003 Dec 01; 168(11):1346-52.Lewinsohn DA, Heinzel AS, Gardner JM, Zhu L, Alderson MR, Lewinsohn DM.  PMID: 12969871.