Current Studies

Precision Genetics for Type 1 Diabetes 

In partnership with University of Chicago, we are looking for people who have T1D and other features that suggest a strong underlying genetic cause to their disease:
  • Families with two or more people with T1D, with or without other immune disorders
  • Individuals with T1D and multiple other autoimmune or inflammatory conditions. Examples of other conditions may include (but are not limited to):
    • Rheumatoid arthritis; Systemic lupus erythematosus (Lupus); Inflammatory bowel disease (IBD); Multiple sclerosis (MS); Psoriasis; Guillain-Barre syndrome; Vitiligo; Hypo- or hyperthyroidism; Mixed connective tissue disease



Endocrine Biobank Study

A study of the characteristics and causes of Endocrine Disorders

The purpose of this study is to gain a better understanding of the mechanisms and genetic risk for various endocrine and hormonal disorders, such as thyroid cancer, obesity, diabetes, and skeletal diseases, among others. We are interested in collecting blood, urine, fat, saliva, and other tissue samples from patients with disorders of the endocrine system as well as healthy patients.

Any UCSF or SFGH patient with the following is eligible.

  • With endocrine or hormonal disease

  • Without hormonal disease but is undergoing planned surgical procedure or is willing to donate blood, saliva or urine

  • Willingness to donate blood, urine, or saliva samples

  • Willingness to donate samples from any planned surgery that would otherwise be discarded.


Autoimmunity and Diabetes Genetics Study

Identification of Novel Diabetes Genes Through Next Generation Sequencing  
  • Any age  

  • For people who: (1) have type 1 diabetes (T1D) and other autoimmune conditions, or (2) have T1D and one or more family members also with T1D, or (3) suspect they have a monogenic form of diabetes, MODY or neonatal diabetes  

  • Saliva collection kits are sent to your home  

  • This is a genetic screen for novel diabetes genes 

  • All data, including genetic results, are confidential, deidentified and not shared outside the research group  

  • Participants are also eligible for a blood draw and follow-up research studies



Autoimmunity Study

Exploring the Genetics of Tissue Specific Autoimmunity

We work to understand what causes the immune system to activate against our normal tissues and cause destruction; in other words, why we get autoimmune disease. To do this, we investigate genetics, autoantibodies and immune cell signatures to better understand autoimmune disease. You are eligible if you have:

  • Autoimmune disease of one or more organs

  • Autoimmune conditions acquired through medical treatment (for example immunotherapy)

  • A family member with autoimmune disease

  • No autoimmune disease (healthy control)