Patrick Ho, PhD

Patrick completed his doctoral training under Yvonne Chen at UCLA, where his work focused on engineering antigen-responsive granzyme B switches to enhance the cytolytic selectivity of adoptive T-cell therapies. 

As a postdoc in the Tang lab, Patrick is applying synthetic biology techniques and single-cell sequencing technologies to elucidate inflammation-induced cell fate decisions in human regulatory T cells (Tregs). The insights gained could inform the design of next-generation Treg therapeutics that better resist conversion into pro-inflammatory cells and more robustly promote immune tolerance in autoimmune and transplant patients.

When not wondering about pathways to different Treg cell fates, Patrick enjoys wandering along hiking paths across different landscapes.