Nitin Amdare, PhD

Nitin Amdare did his master’s in biotechnology from Nagpur University, India, and earned his PhD in Medical Biochemistry from Mahatma Gandhi Institute of Medical Sciences, where he focused on the immunomodulatory potential of filarial parasite-derived molecules in mouse models of T1D and autoimmune diseases, along with the development of vaccines and diagnostics for lymphatic filariasis.

He did his Postdoctoral fellowship at Albert Einstein College of Medicine in DiLorenzo lab, leading key projects advancing T1D research, including the development of human insulin and HLA-transgenic mouse models, preclinical T1D models, and engineered diabetogenic T cells. His work provided important insights into antigen specific T-cell responses involved in T1D and included a successful contribution to solving the crystal structure of T1D-susceptible human MHC-peptide complexes.

In Mark Anderson’s lab, Nitin’s research focuses on mechanisms of immune tolerance and autoimmunity in T1D. He is exploring how defects in thymic selection contribute to the development of autoreactive T cells and autoimmune disease. Drawing on his experience in T-cell biology and mouse models, he aims to identify key factors that regulate immune tolerance and develop strategies to restore immune balance in T1D and related disorders, with a focus on translating these findings into clinical application.