Publications

Selected Publications

 

Tolerance in the Age of Immunotherapy - Anderson M., New England Journal of Medicine, 2020
New Frontiers in the Treatment of Type 1 Diabetes - Anderson M., Cell Metabolism, 2020
Functional CRISPR dissection of gene networks controlling human regulatory T cell identity - Marson A., Nature Immunology, 2020
Evaluation of SARS-CoV-2 serology assays reveals a range of test performance - Marson, A., Nature Biotechnology, 2020
Regulatory T cell control of systemic immunity and immunotherapy response in liver metastasis - Bluestone, J. Science Immunology, 2020
CRISPR screen in regulatory T cells reveals modulators of Foxp3 - Marson A., Nature, 2020
Loss of the transcription factor MAFB limits β-cell derivation from human PSCs Hebrok M. Nature Communications, 2020
Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies - Marson A., Cell, 2020
Emerging route to the generation of functional β-cells for diabetes mellitus cell therapy - Hebrok M., Nature Reviews Endocrinology, 2020
Recapitulating endocrine cell clustering in culture promotes maturation of human stem cell-derived beta cells - Hebrok M., Nature Cell Biology, 2019
A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells - Bluestone J., Immunity, 2019 
Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes - Bhushan A., Cell Metabolism, 2019
Replication confers ß cell immaturity - Hebrok M., Nature Communications, 2018
Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development - Anderson M., Nature, 2018
Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity - Vaisse C., Nature Genetics, 2018 
Lineage dynamics of murine pancreatic development at single-cell resolution - Sneddon J., Nature Communications, 2018
A human anti-IL-2 antibody that potentiates Regulatory T cells by a structure-based mechanism - Bluestone J., Nature Medicine, 2018
Revealing the specificity of regulatory T cells in murine autoimmune diabetes - Tang Q., PNAS, 2018
Reprogramming human T cell function and specificity with non-viral genome targeting - Marson A., Nature, 2018
Dual gene activation and knockout screen reveals directional dependencies in genetic networks - McManus M., Nature Biotechnology, 2018