Halting diabetes: UCSF researchers publish study that points to ways of reversing disease’s onset

UCSF labs of Anil Bhusan, left, and Matthias Hebrok

Members of the UCSF labs of Anil Bhushan, at left, and Matthias Hebrok, at right, collaborated on a study published this week that points at new strategies for treating diabetes. (Photo: Kathleen Jay)

Halting diabetes

UCSF researchers publish study that points to ways of reversing disease’s onset

BY KATHLEEN JAY

Diabetes Center at UCSF

SAN FRANCISCO (June 23, 2015) – This week, novel findings by UCSF researchers Anil Bhushan, PhD, and Matthias Hebrok, PhD, for developing therapeutic strategies to combat diabetes were published in the Journal of Clinical Investigation.

The study, entitled “DNA methylation directs functional maturation of pancreatic beta cells," analyzes how pancreatic beta cells become fully functional after birth.

“Pancreatic beta cells respond to glucose increases after a meal by secreting insulin. On the other end of the spectrum, the cells react to fasting conditions by preventing insulin production,” said Bhushan, a professor at the Diabetes Center at UCSF. “These cells only acquire the ability to secrete insulin in response to changing glucose levels post-natally, indicating that epigenetic mechanisms direct beta cell maturation after birth.”

External or environmental processes can affect how genes are expressed through a process known as epigenetics. If the DNA code for genes are the words in a book, epigenetics are like bookmarks that direct how and if the words are read. External factors can lead to epigenetic alterations, with molecular changes such as DNA methylation,that affect gene expression, without altering the underlying DNA sequence. Thus, epigenetic modifications provide an additional layer of control of how genes are expressed and impact whether a gene is turned “on” (expressed) or “off” (inhibited).

“Our results highlight a novel epigenetic mechanism that governs how beta cells functionally mature during neonatal life and provide new insights into impaired beta cell function in diabetes,” Bhushan said.

To develop these findings, Sangeeta Dhawan, PhD (now an independent scientist at UCLA) in the Bhushan team worked collaboratively with the Hebrok lab, which performed human beta cell analysis for this study.

“Because diseases, such as diabetes, are characterized by beta cell dysfunction which may involve epigenetic changes, we are trying to counteract these modifications with therapeutic, epigenetic treatments,” Bhushan said. “Unlike DNA sequence mutations, epigenetic changes – by nature – appear to be reversible.”

“With Anil’s arrival to UCSF this year, we have elevated beta cell work to new heights,” Hebrok, the director of the Diabetes Center at UCSF said. “This type of research will be highly useful in predicting diseases, such as type 1 diabetes, as well as improving the overall effectiveness of therapeutics to both reduce beta cell destruction and to promote beta cell regeneration.”

For more information, visit http://diabetes.ucsf.edu.

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DNA methylation directs functional maturation of pancreatic beta cells.

Sangeeta Dhawan1, Shuen-ing Tschen1, Chun Zeng1, Tingxia Guo2, Matthias Hebrok2, Aleksey Matveyenko1 and Anil Bhushan1,2
1 Division of Endocrinology, UCLA, Los Angeles, CA 90095, USA.
2 Diabetes Center, UCSF, San Francisco, CA 94143, USA.

Address correspondence to:

Anil Bhushan
Box 0534
513 Parnassus Avenue, Room 1045
Diabetes Center, University of California at San Francisco San Francisco, CA-94143
Phone: (415) 502-3295

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