July 2013 eUpdate
New Ways to Participate in Type 1 Diabetes Clinical Research
The UCSF Pediatric Diabetes Program led by Steve Gitelman, MD, has made progress in altering the course of type 1 diabetes. Through various screening tests, we are now able to identify relatives at risk for developing type 1 diabetes. For those at risk, there are currently three prevention trials that seek to prevent or delay the onset of disease. For those with recent onset of type 1 diabetes, we are exploring ways to preserve any remaining beta cells to prolong the "honeymoon" phase of diabetes progression.
There are two new, easy ways that you and your family members can see if you are eligible for any current or future clinical trials. Through TrialNet, relatives across the country can now screen online to determine if they have the autoantibodies that predict type 1 diabetes. After completing paperwork online, you will receive a test kit that you can take to any Quest lab. www.pathway2prevention.org?11 And, thanks to Anthony Kim, MD, and the CTSI, a web-based screening questionnaire has been developed to quickly assess if participants are eligible for a specific research study. <CTSI Story>
DNA Found Outside of Genes Plays Role in Inherited Disease Risk
A new Diabetes Center study highlights the potential importance of the vast majority of human DNA that lies outside of genes within the cell.
Faculty member Michael McManus, PhD, graduate student Ian Vaughn, and postdoctoral fellow Matthew Hangauer, PhD, identified thousands of previously unknown, unique RNA sequences by looking at which regions of the genome are converted into RNA. RNA is a molecule that increasingly is being found to play myriad important roles within cells. The researchers also determined that this RNA-making DNA is more likely than other non-gene DNA regions to be associated with inherited disease risks. This study may reveal fundamental new insights into diseases like diabetes and pave the way towards developing novel therapeutics that target disease RNAs.
Recently published in PLOS Genetics, this is one of the most comprehensive reviews of the human genome to analyze which stretches of DNA outside of genes make RNA and which do not. <UCSF News Office>
DIABETES CENTER NEWS
Diabetes Center Researcher Receives Prestigious Pew Scholar Award
Shingo Kajimura, PhD, was named a 2013 Pew Scholar in the Biomedical Sciences which provides flexible funding to early-career scientists who are pursuing the most promising, but untried, avenues for scientific breakthroughs. This highly competitive program has granted more than $120 million in funding to over 500 scientists at the beginning of their independent careers.
At UCSF, Dr. Kajimura's lab is focused on understanding how obesity and energy balance are regulated at the molecular level. Dr. Kajimura is a leader in converting white fat cells into a type of brown fat, called "beige" fat, which burns excess energy instead of storing it. Through this innovative approach, he hopes to create new ways to treat both obesity and insulin resistance. <UCSF News Office> <Pew Announcement>
IN THE NEWS
Alzheimer's and Low Blood Sugar in Diabetes May Trigger a Vicious Cycle, UCSF News Office, 6/10/13
The Diabetes Center at UCSF is among the premier institutions for clinical trials of emerging therapies in diabetes. Numerous clinical trials in type 1 and 2 diabetes are now underway. Interested in participating? A sample of our trials is listed below.
TrialNet Natural History Study [Antibody Screening]. Seeking relatives of people with type 1 diabetes, 1 to 45 years of age
Type 1 Diabetes: An Oral Insulin Preventative Study. Seeking relatives of people with type 1 diabetes, 3 to 45 years of age
Type 1 Diabetes: Anti-CD3 mAB (Teplizumab) Preventative Study. Seeking relatives of people with type 1 diabetes, 8 to 45 years of age
Type 1 Diabetes: CTLA-4 lg (Abatacept) Preventative Study. Seeking relatives of people with type 1 diabetes, 6 to 45 years of age
Type 1 Diabetes: Evaluation of Residual Beta Cell Function and Immunologic Features in Patients with Longstanding Type 1 Diabetes. Seeking volunteers 8 years or older who have had type 1 diabetes for five or more years and have a hemoglobin A1c < 9.5%
Type 2 Diabetes: Paleolithic-Type Diets and Metabolic Control. Seeking volunteers 18 years of age and older with type 2 diabetes
Non-Diabetes: Motivational Physical Activity Education Study (mPED). Women between 25 and 69 years of age
Non-Diabetes: A Mobile Phone Based Diabetes Prevention Program (mDPP). Over 35 years of age, overweight, not physically active
APS1 and Autoimmune Disease. Seeking volunteers at least 6 weeks of age who have either autoimmune disease, have evidence of autoimmunity, have a family member with autoimmunity, or do not have autoimmune disease (healthy volunteer control)
For a list of all of our trials, visit the clinical trials section of our website, or contact Lorraine Stiehl.
Diabetes Center at UCSF
If you wish to receive more information about the UCSF Diabetes Center’s clinical and research programs, or would like to financially support one or more of these efforts, please contact Suzanne Ritchie at 415-476-6334. You may also visit our donation webpage and/or designate your donation to the program of your choice.
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